卡麦角林对雄性黄毛鼠社会行为的影响

不育控制既可直接降低害鼠种群的生育率，又能影响个体的社会行为，引起种群内等级关系和社群结构的变化，进而干扰种群繁殖。为探究不同剂量卡麦角林对雄鼠行为的影响和持效时间，选取健康雄性黄毛鼠使用50mg/kg和100 mg/kg卡麦角林灌胃给药，并于给药后第1 d和第18 d与正常雄鼠遭遇，第4 d和第21 d与正常雌鼠遭遇，比较给药前（卡麦角林灌胃前4 d和前1 d 时分别与正常雄鼠和雌鼠遭遇）和给药后个体行为的差异。结果显示：卡麦角林降低了雄鼠对正常雄鼠的探究、攻击时间，降低雄鼠对正常雌鼠的攻击时间和频次；100 μg/kg卡麦角林降低雄鼠对正常雌鼠的探究频次，且雄鼠自身修饰和休息频次显著减少。这表明卡麦角林可干扰黄毛鼠对同性和异性个体间的社会行为。此外，药物处理后第18 d和第21 d，雄性个体与同性和异性个体的社会行为与处理前无显著差异，表明停药后药物对行为的影响会随着时间的延长逐渐消失。 

The effects of cabergoline on social behavior in male Rattus losea

Fertility control reduces the birth rate of rodent populations and influences animal reproductive capability. By contrast, the effects of sterilants on individual behaviors may affect the social hierarchy of populations, and interfere with reproduction in normal animals. To understand the effects of cabergoline treatment dosage and treatment duration on the behavior of male Rattus losea, 40 male rats were randomly divided into five groups and treated with 0, 50, and 100 μg/kg cabergoline for 3 consecutive days. One male subject from the pre-treatment group (T750, T7100) was assigned to dyadic encounters with one subject from the control group (C) on the first day after the end of the three-day treatment. T2450 and T24100 rats encountered the same rat from C on the 18th day after the end of the three-day treatment. T750  and T7100 were assigned to dyadic encounters with normal females on the fourth day after the end of the three-day treatment. T2450 and T24100 rats encountered normal females on the 21st day after the end of the three-day treatment. Social behaviors between the same sex and the opposite sex were observed for 30 min and videotaped. The results showed that cabergoline treatment negatively affected the investigative and aggressive behavior of male R. losea,  and reduced the aggression duration and frequency of males toward females. The frequency of investigation, grooming and resting in males that encountered female counterparts were significantly different between pre- and post-treatment with 100 μg/kg cabergoline. In conclusion, cabergoline treatment disturbs the inter- or intra-sexual social behaviors of R. losea. Furthermore, with longer duration post-treatment, the behavioral data in our experiment were not significantly different compared with pre-treatment. These results indicate that the effects of drug on social behavior of the male can gradually disappear after suspending cabergoline treatment.