The antioxidant activity of phloretin: the disclosure of a new antioxidant pharmacophore in flavonoids |
| |
| Authors: | Rezk Bashir M Haenen Guido R M M van der Vijgh Wim J F Bast Aalt |
| |
| Institution: | Department of Pharmacology and Toxicology, Faculty of Medicine, Universiteit Maastricht P.O. Box 616, 6200 MD Maastricht, The Netherlands. |
| |
| Abstract: | Phloretin is a dihydrochalcone flavonoid that displays a potent antioxidant activity in peroxynitrite scavenging and the inhibition of lipid peroxidation. Comparison with structurally related compounds revealed that the antioxidant pharmacophore of phloretin is 2,6-dihydroxyacetophenone. The potent activity of 2,6-dihydroxyacetophenone is due to stabilisation of its radical via tautomerisation. The antioxidant pharmacophore in the dihydrochalcone phloretin, i.e., the 2,6-dihydroxyacetophenone group, is different from the antioxidant pharmacophores previously reported in flavonoids. |
| |
| Keywords: | Phloretin Dihydrochalcone Flavonoid Peroxynitrite Lipid peroxidation |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
