Changes in developmental profiles of brain gangliosides during ontogeny of a teleost fish (Sarotherodon mossambicus,Cichlidae) |
| |
Authors: | Volker Seybold Hinrich Rahmann |
| |
Institution: | (1) Institute of Zoology, University of Stuttgart-Hohenheim, D-7000 Stuttgart 70 (Hohenheim), Federal Republic of Germany |
| |
Abstract: | Summary Ontogenetic changes of brain ganglioside concentration and composition have been followed in the teleost fishSarotherodon mossambicus Cichlidae) from the 1st day post hatching to the adult stage, in order to correlate these with findings in higher vertebrates. During the developmental period from hatching to the transition to free swimming, which comes along with maximum rate of synaptogenesis, a sharp rise in the brain ganglioside content occurs, which is mainly due to the trisialoganglioside GT1b. In the following phase of myelination (characterized in birds and mammals by an increase in GM1, GM1 and GM4) accretion of the novel and so far unidetified fraction (GM2) occurs, which is highly enriched in the brain stem. The results obtained are discussed with respect to gangliosides as useful biochemical markers for brain development and maturation in all vertebrates. |
| |
Keywords: | Ontogeny Teleost fish Brain gangliosides Sialo-glycoproteins Sialic acid Sarotherodon mossambicus |
本文献已被 SpringerLink 等数据库收录! |
|