Novel Biological Process for L-DOPA Production from L-Tyrosine by P-Hydroxyphenylacetate 3-Hydroxylase |
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| Authors: | Jang-Young Lee Luying Xun |
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| Affiliation: | (1) Environmental Microbiology Group, Battelle Pacific Northwest National Laboratory, PO Box 999, K4-06, Richland, WA 99352, USA;(2) Present address: Pacific R&D center, 314-1, Bora-ri, Kiheung-eup, Yongin-si, Kyonggi-do, 449-900, KOREA;(3) Department of Microbiology, Washington State University, Pullman, WA 99164-4233, USA |
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| Abstract: | A novel biological method was developed for the production of L-3,4-dihydroxyphenylalanine (L-DOPA) from L-tyrosine by p-hydroxyphenylacetate 3-hydroxylase of Escherichia coli strain W (ATCC 11105). About 48 mM (or 1% w/v) L-DOPA was obtained by a fed batch operation in 50 h when a recombinant strain constitutively producing the enzyme was used. |
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