Serum B-cell activating factor predicts prognosis in nasal type,extranodal NK/T cell lymphoma |
| |
| Affiliation: | 1. Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan;2. Division of Molecular Therapy, Institute of Medical Science, The University of Tokyo, Tokyo, Japan;3. Research Core, Institute of Research, Tokyo Medical and Dental University, Tokyo, Japan;4. Department of Immunology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan;5. Department of Biochemistry, Jichi Medical University, Tochigi, Japan;6. Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan;7. CDM Center, Takara Bio, Shiga, Japan;8. Department for Immuno-Gene Therapy, Mie University Graduate School of Medicine, Mie, Japan;9. Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan;10. Japan Science and Technology Agency, Precursory Research for Embryonic Science and Technology, Saitama, Japan;11. Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan |
| |
| Abstract: | B-cell activating factor (BAFF) plays important roles in a variety of lymphoid malignancies. Compared with healthy adults, patients with non-Hodgkin lymphoma had higher level of serum BAFF, and it corresponded with disease severity, response for therapy and clinical outcome. Latent membrane protein 1 (LMP1) encoded by Epstein-Barr virus (EBV) which is a known agent of nasal, extranodal NK/T cell lymphoma (ENKTCL) can switch the BAFF activating promoter leading to higher expression of BAFF in EBV-related tumor cells. However, the relationship between BAFF and ENKTCL has not been reported. Here we proposed a hypothesis that BAFF might play a regulatory role in ENKTCL development and maintenance. Our results showed that serum BAFF in ENKTCL patients was significantly higher than that in control group and negatively correlated with patients’ survival. It may be a valuable prognostic factor and deserved further study. |
| |
| Keywords: | B cell activating factor (BAFF) Nasal type Extranodal NK/T cell lymphoma (ENKTCL) Prognosis |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
