Levels of serum pentraxin 3, IL-6, fetuin A and insulin in patients with rheumatoid arthritis |
| |
| Institution: | 1. Cardiovascular Research Center, CSIC-ICCC, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Barcelona, Spain;2. Cardiovascular Research Chair, UAB, Barcelona, Spain;1. EMMRC, Anna University Campus, Guindy, Chennai 600 025, Tamil Nadu, India;2. Department of Genetics, Dr. ALM PG Institute of Basic Medical Science, University of Madras, Tamilnadu, India;3. Department of Biochemistry and Molecular Genetics, Prof. M. Viswanathan Diabetes Research Centre and M.V. Hospital for Diabetes (A WHO Collaborating Centre for Research, Education & Training in Diabetes), International Diabetes Federation, Centre of Education and Centre of Excellence in Diabetes Care, Royapuram, Chennai, -600 013, Tamilnadu, India;4. SRM Research Institute and Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur, Chennai, Tamil Nadu 603 203, India;1. From the Department of Endocrinology & Metabolism, Institute of Post-Graduate Medical Education & Research (IPGMER) and Seth Sukhlal Karnani Memorial (SSKM) Hospital, Calcutta, India,;2. Department of Biochemistry, Dr. B C Roy Post-Graduate Institute of Basic Medical Education and Research, IPGMER & SSKM Hospital, Calcutta, India, and;3. Department of Endocrinology, Post-Graduate Institute of Medical Education & Research & Dr. Ram Manohar Lohia Hospital, New Delhi, India. |
| |
| Abstract: | ObjectiveThe aim of this study was to investigate the relationship between disease severity and biochemical parameters such as pentraxin-3, fetuin-A, IL-6, insulin and HOMA-IR levels in patients with rheumatoid arthritis.MethodsThis study included 60 patients with RA and 20 healthy controls. Serum pentraxin-3, fetuin-A, IL-6 and insulin concentrations were measured. Also, HOMA-IR values were calculated. Disease activity was assessed with Disease Activity Score (DAS28). To evaluate quality of life, the Health Assessment Questionnaire disability index was applied.ResultsThe serum values for ESR, CRP, pentraxin-3 and fetuin-A in patients with RA were found to be higher than control subjects (p values = 0.001, 0.001, 0.000, 0.000, 0.01, 0.02, respectively). A positive correlation was evident between the DAS 28 score and IL6 levels (r = 0.263, p = 0.045). We found no correlation between the DAS28 score and HOMA-IR, the levels of pentraxin 3, fetuin A, insulin (p < 0.05). Fetuin A levels were positively correlated with cumulative steroid dose (r = 0.382, p = 0.035). A statistically significant correlation was evident between presence of cardiovascular disease and HOMA-IR values in RA patients (r = 0.437, p = 0.032).ConclusionElevated levels of pentraxin-3, fetuin-A, CRP, ESR might play a role in the pathogenesis of RA. Levels of fetuin-A, insulin HOMA-IR, pentraxin-3, CRP and ESR were not associated with clinical severity of the RA. |
| |
| Keywords: | Inflammatory markers Pentraxin 3 Rheumatoid arthritis |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
