Serum levels of GDF15 are reduced in preeclampsia and the reduction is more profound in late-onset than early-onset cases |
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| Institution: | 1. The Hospital of Obstetrics & Gynaecology, Fudan University, China;2. Department of Obstetrics & Gynaecology, University of Auckland, New Zealand;3. Centre for Reproductive Health, Hudson Institute of Medical Research, Clayton, VIC, Australia;4. Department of Molecular and Translational Sciences, Monash University, Clayton, VIC, Australia;5. Wuxi Maternity and Children’s Health Hospital, Nanjing Medical University, Jiangsu, China;6. Central Clinical School, University of Sydney, Sydney, NSW, Australia;7. RPA Women and Babies, Royal Prince Alfred Hospital, Sydney, NSW, Australia;8. Monash Ultrasound for Women, Melbourne, VIC, Australia;9. Department of Biochemistry and Molecular Biology, Monash University, Australia;1. Gynecology and Obstetrics Department, Shanghai Tenth People’s Hospital affiliated to School of Medicine, Tongji University, Shanghai, China;2. Cardiology Department, Shanghai Worldpath Clinic International, Shanghai, China;3. Endocrinology Department, Tongji Hospital affiliated to School of Medicine, Tongji University, Shanghai, China;1. Department of Cardiology, Institute for Clinical and Experimental Medicine-IKEM, Prague, Czech Republic;2. Center for Cardiovascular Prevention of the First Faculty of Medicine, Charles University and Thomayer Hospital, Prague, Czech Republic;3. Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA;4. Department of Laboratory Methods, Institute for Clinical and Experimental Medicine-IKEM, Prague, Czech Republic;5. Third Faculty of Medicine, Charles University, Prague, Czech Republic;1. Department of Obstetrics & Gynaecology, First Affiliated Hospital of Xi’an Jiaotong University, China;2. Department of Obstetrics & Gynaecology, Third Affiliated Hospital of Sun-Yat Sen University, Guangzhou, China;3. The Hospital of Obstetrics & Gynaecology, Fudan University, China;4. Department of Obstetrics & Gynaecology, The University of Auckland, New Zealand;1. Department of Neurology and Neuromuscular Reference Centre, Ghent University Hospital, Ghent, Belgium;2. Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium |
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| Abstract: | BackgroundPreeclampsia is a pregnancy specific disorder affecting 3–5% of pregnancies worldwide. It is clinically divided into early-onset and late-onset subtypes. Placental factors are involved in the pathogenesis of preeclampsia. Growth differentiation factor 15 (GDF15), a protein of the transforming growth factor beta superfamily, is highly expressed in the placenta. However, it is unclear whether the circulating levels of GDF15 are altered in preeclampsia at the time of or prior to disease presentation.MethodsSerum samples across three trimesters from 29 healthy pregnancies, third trimester sera from 34 women presenting with preeclampsia (early-onset n = 16, late-onset n = 18) and 66 gestation-age-matched controls, and sera at 11–13 weeks of pregnancy from women who later did (n = 36) or did not (n = 33) develop late-onset preeclampsia, were examined for GDF15 by ELISA.ResultsSerum GDF15 levels increased significantly with gestation in normal pregnancy. Serum GDF15 was significantly reduced in the third trimester in women presenting with preeclampsia compared to their gestation-age-matched controls. This reduction was apparent in both early-onset and late-onset subtypes, but it was more profound in late-onset cases. At 11–13 weeks of gestation, however, serum levels of GDF15 were similar between women who subsequently did and did not develop late-onset preeclampsia.ConclusionSerum GDF15 increased with gestation age, reaching the highest level in the third trimester. Serum GDF15 was significantly reduced in the third trimester in women presenting with preeclampsia, especially in late-onset cases. However, serum GDF15 was not altered in the first trimester in women destined to develop late-onset preeclampsia. |
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| Keywords: | Preeclampsia Serum GDF15 Early-onset and late-onset preeclampsia |
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