Effects of omega-3 fatty acids on serum levels of T-helper cytokines in children with asthma |
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| Institution: | 1. Department of Immunology, Shiraz University of Medical Sciences, Shiraz, Iran;2. Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;3. Prof. Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;4. Paramedical School, Hormozgan University of Medical Science, Bandar Abbas, Iran;1. Key Laboratory of Metabolism and Molecular Medicine, The Ministry of Education, Department of Biochemistry and Molecular Biology, Fudan University Shanghai Medical College, Shanghai, China;2. Department of Interventional Vascular Surgery, Binzhou Medical College Hospital, Binzhou, Shandong Province, China;3. Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China;4. Department of Cerebrovascular Neurosurgery, Binzhou Medical College Hospital, Binzhou, Shandong Province, China;5. Department of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China;1. Department of Immunology, Professor Alborzi Clinical Microbiology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran;2. Shiraz University of Medical Sciences, Shiraz, Iran;3. Department of Immunology, Shiraz Medical Schools, Shiraz University of Medical Sciences, Shiraz, Iran;1. Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Iran;2. Department of Immunology, Professor Alborzi Clinical Microbiology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran;3. Department of Vascular Surgery, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;1. Department of Immunology, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran;2. Infectious and Tropical Diseases Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran;3. Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran;4. Cardiovascular Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran;5. Department of Molecular Biology, Pasteur Institute of Iran, Tehran, Iran;6. Molecular Medicine Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran;7. Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran |
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| Abstract: | BackgroundThere has been a considerable interest in the potential therapeutic value of dietary supplementation with ω-3 fatty acids in patients with asthma.ObjectivesThis cross-sectional study was designed to identify the effect of ω-3 fatty acids on symptom score, pulmonary function and serum T-helper cytokine concentrations in children with mild to moderate persistent asthma.MethodsA total of 39 patients among 50 volunteers completed this 3-month study. They took a soft gel capsule containing 180 mg EPA and 120 mg DHA daily. Pulmonary function was evaluated in 28 eligible patients by spirometry, and serum levels of Th1, Th2, Th9, Th17 and Th22 cytokines were measured by multiplex cytometric bead assay before and after treatment.ResultsAfter treatment with ω-3, symptom score improved in 28 (72%) patients. The results of spirometry showed remarkable improvement in FEV1/FVC (P = 0.044) and PEF (P < 0.0001) after treatment, but considering a cut-off of 80%, real improvement was observed in 32% of patients with PEF < 80% which raised above the cut-off after ω-3 treatment (P = 0.004) whereas, FEV1/FVC changes were above the cut-off value in 89% of the patients. After treatment, IL-17A and TNF-α levels decreased significantly (both P = 0.049).ConclusionOral administration of natural anti-inflammatory products such as ω-3 is a promising complementary approach to managing asthma. |
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| Keywords: | Asthma Cytokines Cytometric bead assay Lung function Omega-3 |
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