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Influence of genetic polymorphisms of cytokine genes in the outcome of HLA-matched allogeneic stem cell transplantation in a South East Asian population
Affiliation:1. Department of Medicine, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia;2. Department of Pathology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia;3. Subang Jaya Medical Centre, Subang Jaya, Selangor, Malaysia;1. Renal and Pancreas Transplant Division, Saint Barnabas Medical Center, Livingston, New Jersey, USA;2. Rutgers School of Public Health, Department of Epidemiology, Piscataway, New Jersey, USA;3. Ronald O. Perelman Department of Emergency Medicine, New York University School of Medicine, New York, New York, USA;4. Department of Population Health, New York University School of Medicine, New York, New York, USA;1. Instituto Nacional de Genetica Medica Populacional, Departamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil;2. Department of Immunology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil;3. Programa de Pós-Graduação em Genética e Biologia Molecular, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil;1. International Collaborative Donor Project, Murcia, Spain;2. Department of Surgery, Paediatrics, Obstetrics and Gynaecology, University of Murcia, Spain;3. Transplant Unit, Surgery Service, IMIB—Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain;4. Department of Psychology, Catholic University of Murcia, Murcia, Spain;5. Hospital Regional de Alta Especialidad del Bajío, León, Guanajuato, Mexico;6. Organización Nacional de Trasplantes (ONT), Spain;7. Coordinación de Trasplantes, UMAE Hospital de Especialidades, Monterrey, México;8. Department of Animal Production, the Faculty of Veterinary Medicine, University of Murcia, Spain;9. Endocrinology and Nutrition Service, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain;1. HLA & Immunogenetics Laboratory, Department of Transfusion Medicine, Tata Memorial Hospital, Parel, Mumbai 400012, India;2. Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA 92037, USA;1. Proyecto Colaborativo Internacional Donante (International Collaborative Donor Project), Murcia, Spain;2. Department of Surgery, Pediatrics, Obstetrics and Gynecology, University of Murcia, Murcia, Spain;3. Transplant Unit, Surgery Service, IMIB–Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain;4. Department of Psychology, Universidad Católica San Antonio, UCAM, Murcia, Spain;5. Hospital Regional de Alta Especialidad del Bajío, León, Guanajuato, Mexico;6. Regional General Hospital No. 58 of the IMSS, Delegación Guanajuato, México;7. Escuela de Medicina de la Universidad de Quetzalcoatl en Irapuato, México;8. Endocrinology and Nutrition Service, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain;9. Regional Transplant Centre, Consejería de Sanidad y Consumo de la Región de Murcia, Murcia, Spain;1. Proyecto Colaborativo Internacional Donante (“International Collaborative Donor Project”), Murcia, Spain;2. Department of Surgery, Paediatrics, Obstetrics y Gynaecology, University of Murcia, Murcia, Spain;3. Transplant Unit, Surgery Service, IMI—Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain;4. Department of Psychology, Catholic University of Murcia, UCAM, Murcia, Spain;5. Hospital Regional de Alta Especialidad del Bajío, León, Guanajuato, Mexico;6. Organización Nacional de Trasplantes (ONT), Madrid, Spain;7. Coordinación de Trasplantes, UMAE Hospital de Especialidades No. 25 IMSS, Monterrey, Mexico;8. Department of Animal Production, The Faculty of Veterinary Medicine, University of Murcia, Murcia, Spain;9. Endocrinology and Nutrition Service, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain
Abstract:Non-HLA gene polymorphisms have been shown to be associated with the risk of graft-versus-host disease (GVHD) and outcome of allogeneic haematopoietic stem cell transplantation (AHSCT). This study aims to investigate the role of IL6, TNFα, IL10, IL2 and IL12 gene polymorphisms in the outcome of AHSCT in a South East Asian population. A total of 67 patients and 59 donors who underwent HLA-identical matched sibling AHSCT were available for analysis. There was no significant association between the different cytokine genotypes of patients with the incidence and severity of acute GVHD. Patients with IL2 1661T allele and patients who received donor stem cells who had IL2 1661G allele appeared to have reduced incidence of cGVHD. Patients who received donor stem cells with IL12 11881C allele are found to be associated with better disease free survival. These results suggest a possible role of IL2 and IL12 gene polymorphisms in the outcome of AHSCT in a South East Asian population.
Keywords:Cytokine gene polymorphism  Allogeneic stem cell transplantation  Interleukin  Graft versus host disease
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