Salivary levels of inflammatory cytokines and their association to periodontal disease in systemic lupus erythematosus patients. A case-control study |
| |
| Institution: | 1. School of Dentistry, Federal University of Maranhão, Avenida dos Portugueses, s/n, Campus Universitário do Bacanga, 65.085-580 São Luís, MA, Brazil;2. Service Rheumatology of University Hospital, Federal University of Maranhão, Rua Barão de Itapari, 227 - Centro, São Luís, MA 65020-070, Brazil;3. Phytor Lab for Drug Development, The Hadassah Medical Center Hebrew University Biotechnology Park (JBP), Ein Kerem Campus, Jerusalem 91120, Israel;4. Department of Physiological Sciences, Federal University of Maranhão, Avenida dos Portugueses, s/n, Campus Universitário do Bacanga, 65.085-580 São Luís, MA, Brazil;1. Department of Oral Science, Division of Environmental Pathology, Kanagawa Dental University, Graduate School of Dentistry, Kanagawa, Japan;2. Department of Oral Science, Division of Dental Anatomy, Kanagawa Dental University, Graduate School of Dentistry, Kanagawa, Japan;3. Department of Dental Hygiene, Kanagawa Dental University, Junior College, Kanagawa, Japan;4. Department of Microbiology and Infection, Kanagawa Dental University, Graduate School of Dentistry, Kanagawa, Japan;5. Department of Pathology, Yokosuka Kyosai Hospital, Kanagawa, Japan;6. Department of Dental Sociology, Kanagawa Dental University, Graduate School of Dentistry, Kanagawa, Japan;1. Unit of Periodontology, UCL Eastman Dental Institute, 256 Gray''s Inn Road, London WC1X 8LD, United Kingdom;2. Biostatistics Unit, UCL Eastman Dental Institute, 256 Gray''s Inn Road, London, United Kingdom;3. Vascular Physiology Unit, Great Ormond Street Hospital, 34 Great Ormond Street, London, United Kingdom;4. Faculty of Population Health Sciences, Institute of Cardiovascular Science, UCL, 1–19 Torrington Place, London, United Kingdom;1. Department of Internal Medicine, Groupe Hospitalier Sud Ile de France, 77000, Melun, France;2. Department of Infectious Diseases, Nord Franche-Comté Hospital, 90400, Trévenans, France;3. Department of Clinical Immunopathology, Saint-Louis Hospital, University of Paris, 75010, Paris, France;1. Department of Population, Family, and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, MD, USA;2. Institute for Interdisciplinary Salivary Bioscience Research, University of California, Irvine, CA, USA;3. Sanford School of Social and Family Dynamics, Arizona State University, Tempe, AZ, USA;4. Department of Psychology, Arizona State University, Tempe, AZ, USA;5. Department of Acute and Chronic Care, Johns Hopkins University School of Nursing, MD, USA;6. Department of Pediatrics, Johns Hopkins University School of Medicine, MD, USA;7. Institute for Genomic Medicine, Johns Hopkins University School of Medicine, MD, USA;8. Salimetrics Research and Technology Center, Carlsbad, CA, USA;9. School of Dental Sciences, Newcastle University, Newcastle upon Tyne, UK;10. Salivary Bioscience Laboratory and Department of Psychology, University of Nebraska, Lincoln, USA |
| |
| Abstract: | Both Systemic Lupus Erythematosus (SLE) and periodontal disease (PD) present a similar immunological profile mainly characterized by altered cytokine levels. In this study we sought to investigate the salivary levels of inflammatory cytokines and their association with PD in SLE patients. 60 patients with SLE and 54 systemically healthy individuals underwent a full periodontal clinical examination. They were then grouped according to their periodontal status. Stimulated saliva was collected in order to evaluate the salivary levels of interferon (IFN-γ), Interleukin (IL)-10, IL-17, IL-1β, and IL-4. Systemically healthy individuals with periodontitis (group P) presented higher levels of cytokines when compared to systemically healthy individuals, with no periodontal disease (group S) (p < 0.05). Additionally, in the P group, patients presented similar levels of cytokines to those of the patients with SLE, regardless of the presence of PD (p > 0.05), for most of the analyzed cytokines. There was a positive correlation in SLE patients, including IL-1β and all periodontal clinical parameters (p < 0.05), and between IL-4 and gingival bleeding index and the presence of biofilm (p < 0.05). Thus, our results confirmed, that patients with PD showed higher salivary levels of cytokines and, in SLE patients, the increased levels of salivary cytokines were observed even in the absence of periodontitis. IL-1β and IL-4 salivary levels were also positively correlated with periodontal status indicating their potential as markers of the amount and extent of periodontal damage in patients with SLE. |
| |
| Keywords: | Periodontitis Systemic lupus erythematosus Saliva Biological markers |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
