Therapeutic utility of the newly discovered properties of interleukin-21 |
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| Institution: | 1. Department of Immunology, College of Basic Medical Science, China Medical University, Shenyang, Liaoning 110122, China;2. Dalian Institute of Biotechnology, Dalian, Liaoning, China;3. Department of Laboratory Medicine, The First Hospital of China Medical University, Shenyang, Liaoning 110001, China;4. Department of Pathogen Biology and Immunology, Kunming Medical University, Kunming, China;5. Program in Public Health, University of California, Irvine, CA, USA;6. Department of Entomology, The Pennsylvania State University, University Park, PA 16802, USA |
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| Abstract: | Since its discovery in 2000, interleukin-21 (IL-21) has been shown to display a broad spectrum of pleiotropic actions including the regulation of development, differentiation and function of lymphoid-myeloid cells. More specifically, IL-21 modulates the effector functions of T, B and NK cells, which not only have key roles in antitumoral and antiviral immunity but also in exerting major effects on inflammatory responses promoting the development of autoimmune diseases. Recent studies have unveiled an unexpected role for IL-21 in immune regulation and de novo T-cell development. While highlighting its critical role in immunity, this review will mainly focus on recent advances in IL-21 biology and how such newly discovered properties could potentially be exploited therapeutically in the establishment of future clinical trials. |
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