1alpha,25(OH)2D3 induces capacitative calcium entry involving a TRPC3 protein in skeletal muscle and osteoblastic cells |
| |
Authors: | Santillán G Katz S Buitrago C Boland R |
| |
Institution: | Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur, San Juan 670 (B8000CN), Bahía Blanca, Argentina. |
| |
Abstract: | This work describes the involvement of TRPC proteins in capacitative calcium entry (CCE) induced by 1alpha,25-dihydroxy-vitamin-D3 1alpha,25(OH)2D3] in chick skeletal muscle and in rat osteoblast-like cells (ROS 17/2.8) and the role of the vitamin D receptor (VDR) in this non-genomic rapid response mediated by the hormone. We propose that an endogenous TRPC3 protein mediates 1alpha,25(OH)2D3 modulation of CCE in these cells, which seems to implicate VDR-TRPC3 association and the participation of an INAD-like scaffold protein. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|