Dunaliella as an attractive candidate for molecular farming |
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Authors: | Abolfazl Barzegari Mohammad Amin Hejazi Nahid Hosseinzadeh Solat Eslami Elnaz Mehdizadeh Aghdam Mohammad Saeid Hejazi |
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Institution: | (1) Department of Food Biotechnology, Branch of West and North-West Region of Iran (Tabriz), Agricultural Biotechnology Research Institute of Iran (ABRII), Karaj, Iran;(2) Faculty of Agriculture, Tabriz University, Tabriz, Iran;(3) Faculty of Biology Science, Shahid Beheshty University, Tehran, Iran;(4) Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran |
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Abstract: | Pharmaceutical recombinant proteins are widely used in human healthcare. At present, several protein expression systems are
available to generate therapeutic proteins. These conventional systems have distinct advantages and disadvantages in protein
yielding; in terms of ease of manipulation, the time required from gene transformation to protein purification, cost of production
and scaling-up capitalization, proper folding and stability of active proteins. Depending on the research goal and priorities,
a special system may be selected for protein expression. However, considering the limited variety of organisms currently used
and their usage restrictions, there are still much more pharmaceutical proteins waiting to be economically and efficiently
produced. Distinguished biological and technical features of microalgae Dunaliella such as inexpensive medium requirement,
fast growth rate, the ease of manipulation, easy scaling up procedure, facility of milking in bioreactors and the ability
of post-translational modifications make this microorganism an attractive candidate for molecular farming. |
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