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Bicyclo[2.2.1]heptanes as novel triple re-uptake inhibitors for the treatment of depression |
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| Authors: | Axford Lorraine Boot John R Hotten Terrence M Keenan Martine Martin Fionna M Milutinovic Sandra Moore Nick A O'Neill Michael F Pullar Ian A Tupper David E Van Belle Kristel R Vivien Vincent |
| Affiliation: | Lilly Research Centre, Erl Wood Manor, Sunninghill Road, Windlesham, Surrey GU20 6PH, UK. |
| Abstract: | A series of substituted naphthyl containing chiral [2.2.1] bicycloheptanes were prepared utilizing asymmetric Diels-Alder chemistry. This paper describes structure-activity relationships in this series. The N-methyl 2-naphthyl analogue (16d) and its des-methyl analogue (17d) are active triple re-uptake inhibitors both in vivo and in vitro. |
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