Anti-leukemia activity of 7-hydroxy-2-substituted-methyl-5H-oxazolo[3,2-a]pyrimidin-5-one derivatives |
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| Authors: | Guillon Jean Mamani-Matsuda Maria Massip Stephane Leger Jean-Michel Thiolat Denis Mossalayi Djavad Jarry Christian |
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| Institution: | EA 2962-Pharmacochimie, Université Victor Segalen Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux cedex, France. |
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| Abstract: | The synthesis of new 7-hydroxy-2-substituted-methyl-5H-oxazolo3,2-a]pyrimidin-5-ones derivatives, designed as structural bicyclic analogues of the iron chelator deferiprone, is described. They were tested for their ability to inhibit proliferation in human Bcr-Abl+ leukemia cells. |
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