1.Innere Medizin III,Universit?t Heidelberg,Heidelberg,Germany;2.Praxis für Kardiologie/Pneumologie,K?ln,Germany
Abstract:
Summary The accumulation and proliferation of vascular smooth muscle cells (VSMC) within the vessel wall is an important pathogenic
feature in the development of atherosclerosis. Glucose metabolism has been implicated to play an important role in this cellular
mechanism. To further elucidate the role of glucose metabolism in atherogenesis, glycolysis and its regulation have been investigated
in proliferating VSMC. Platelet derived growth factor (PDGF BB)-induced proliferation of VSMCs significantly stimulated glucose
flux through glycolysis. Further evaluating the enzymatic regulation of this pathway, the analysis of flux:metabolite co-responses
revealed that anaerobic glycolytic flux is controlled at different sites of gycolysis in proliferating VSMCs, being consistent
with the concept of multisite modulation. These findings indicate that regulation of glycolytic flux in proliferating VSMCs
differs from traditional concepts of metabolic control of the Embden–Meyerhof pathway.