硝酸舍他康唑乳膏每日1次疗法治疗股癣疗效观察

目的 观察舍他康唑乳膏1次/d疗法治疗股癣的效果与安全性.方法 将参与试验的股癣患者随机分组,试验组每晚1次外用舍他康唑乳膏,对照组早晚各1次外用舍他康唑乳膏,连续用药4周,于治疗前、用药2周、4周及停药后2周分别进行症状和体征评分.结果 治疗结束和停药2周时,两组的临床疗效无显著差异(P＞0.05).治疗2周时试验组和对照组的真菌清除率分别为82.6％和92.5％,有显著差异(P＜0.05)；治疗结束和停药2周时试验组的真菌清除率分别为95.9％和97.3％,对照组分别为96.4％和98.6％,均无显著差异(P＞0.05).结论 舍他康唑乳膏1次/d疗法治疗股癣疗效好,简便易行,安全性高.

Efficacy of once-daily treatment with sertaconazole cream in patients with tinea cruris

Objective To observe the efficacy and safety of once-daily sertaconazole cream in treatment of tinea cruris.Methods Patients with tinea cruris were treated with sertaconazole cream for 4 weeks and were randomly enrolled into trial group （once daily） or control group （twice daily）.The clinical observations were taken before and after 2 week ,4 week treatment, and 2 weeks after the treatment.Results The clinical and mycological effects of 2 groups had no statistically significant difference （P〉0.05） at the end of 4 week treatment and 2 weeks after the treatment. But the mycological effects of 2 groups showed statistically significant difference （P〈0.05）after 2 week treatment.Conclusions Once-daily Sertaconazole cream is effective and safe in the treatment of tinea cruris.