Bi-cycling the furin pathway: from TGN localization to pathogen activation and embryogenesis |
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Authors: | Molloy S S Anderson E D Jean F Thomas G |
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Institution: | Vollum Institute, Oregon Health Sciences University, Portland 97201, USA. |
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Abstract: | Furin is a secretory pathway endoprotease that catalyses the maturation of a strikingly diverse group of proprotein substrates, ranging from growth factors and receptors to pathogen proteins, in multiple compartments within the trans-Golgi network (TGN)/endosomal system. This review focuses on recent developments in the biochemistry and cell biology of the endoprotease, including the mechanism of TGN localization, phosphorylation-dependent regulation of protein traffic, and novel insights into early embryogenesis, extracellular matrix formation and pathogen virulence. |
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