The mutagenicity testing of tertiary-butyl alcohol, tertiary-butyl acetate™ and methyl tertiary-butyl ether in Salmonella typhimurium |
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Authors: | D.B. McGregor G. Cruzan R.D. Callander K. May M. Banton |
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Affiliation: | aToxicity Evaluation Consultants, 38 Shore Road, Aberdour KY3 0TU, UK;bToxWorks, 1153 Roadstown Road, Bridgeton, NJ 08302-6640, USA;cCentral Toxicology Laboratory, Alderley Park, Macclesfield, SK10 4TJ, UK;dHuntingdon Life Sciences Ltd., Woolley Road, Alconbury, Huntingdon PE28 4HS, UK;eEquistar Chemicals, LP, Lyondell Chemical Company, One Houston Center, Suite 1600, 1221 McKinney Street, Houston, TX 77010, USA |
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Abstract: | Tertiary-Butyl alcohol (TBA), tertiary-butyl acetate™ (TBAc™) and methyl tertiary-butyl ether (MTBE) are chemicals to which the general public may be exposed either directly or as a result of their metabolism. There is little evidence that they are genotoxic; however, an earlier publication reported that significant results were obtained in Salmonella typhimurium TA102 mutagenicity tests with both TBA and MTBE. We now present results of testing these chemicals and TBAc™ against S. typhimurium strains in two laboratories. The emphasis was placed on testing with S. typhimurium TA102 and the use of both dimethyl sulphoxide and water as vehicles. Dose levels up to 5000 μg/plate were used and incubations were conducted in both the presence and absence of liver S9 prepared from male rats treated with either Arochlor 1254 or phenobarbital-β-naphthoflavone. The experiments were replicated, but in none of them was a significant mutagenic response observed, thus the current evidence indicates the TBA, TBAc™ and MTBE are not mutagenic in bacteria. |
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Keywords: | Salmonella typhimurium Methyl tertiary-butyl ether tertiary-Butyl alcohol Dimethylsulphoxide tertiary-Butyl acetate |
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