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Cytotoxic T cells and mycobacteria
Authors:Silva C L  Bonato V L  Lima K M  Coelho-Castelo A A  Faccioli L H  Sartori A  De Souza A O  Leão S C
Institution:Department of Biochemistry and Immunology, School of Medicine of Ribeir?o Preto, University of S?o Paulo, Brazil. clsilva@fmrp.usp.br
Abstract:How the immune system kills Mycobacterium tuberculosis is still a puzzle. The classical picture of killing due to phagocytosis by activated macrophages may be only partly correct. Based on recent evidence, we express here the view that cytotoxic T lymphocytes also make an important contribution and suggest that DNA vaccines might be a good way to enhance this.
Keywords:Cytotoxic T lymphocyte  Macrophage activation  Cellular immune response  DNA vaccine  Gene therapy              Mycobacterium tuberculosis
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