Cytogenetic studies on three pheochromocytomas derived from patients with von Hippel-Lindau syndrome |
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Authors: | Marion Kiechle-Schwarz Hartmut P H Neumann Hans-Joachim H Decker Claudia Dietrich Bernd Wullich Werner Schempp |
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Institution: | (1) Institut für Humangenetik und Anthropologie der Universität, Albertstrasse 11, D-7800 Freiburg i. Br., Germany;(2) Abteilung für Nephrologie und Hypertonie, Medizinische Klinik der Universität, Hugstetterstrasse 55, D-7800 Freiburg i.Br., Germany;(3) Cancer Center of Southwest Biomedical Research Institute, Scottsdale, Arizona, USA;(4) Abteilung Humangenetik der Universität, Postfach 4066, D-7900 Ulm, Germany |
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Abstract: | Summary Chromosomal analyses of three pheochromocytomas from patients with von Hippel-Lindau syndrome are reported. One pheochromocytoma revealed a normal karyotype, another tumor showed a trisomy 7 as the only chromosomal abnormality, whereas in a further sample a polyclonal chromosome constitution was detected. In addition to a normal 46,XX cell line, four distinct chromosomally abnormal cell lines could be identified. One cell line revealed partial trisomy for the long arm of chromosome 1 and additionally exhibited the phenomenon of telomeric association. Most interestingly, three further cell clones showed rearrangements of chromosome 3 including the region where the von Hippel-Lindau gene was mapped; three rearrangements resulted in a partial or total trisomy of 3p. Our findings are discussed in relation to previously reported cytogenetic and molecular results regarding von Hippel-Lindau syndrome. |
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