Histamine release as the basis for morphine action on bile duct and sphincter of Oddi |
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| Authors: | S Ehrenpreis I Kimura T Kobayashi M Kimura |
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| Affiliation: | 1. Anesthesiology and Intensive Care Clinic, Clinical Hospital Center Rijeka, Rijeka, Croatia;2. Department of Physiology and Immunology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia;3. Clinical Institute of Laboratory Diagnostics, Clinical Hospital Center Rijeka, Rijeka, Croatia;4. Gynecology and Obstetrics Clinic, Clinical Hospital Center Rijeka, Department of Gynecology and Obstetrics, Faculty of Medicine, University of Rijeka, Rijeka, Croatia;1. Anesthesia and Operation Center, Chinese PLA General Hospital, Beijing 100853, China;2. Department of Anesthesiology, The General Hospital of the PLA Rocket Force, Beijing, China;3. State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, China |
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| Abstract: | We have investigated the mechanism by which morphine contracts hog bile duct and sphincter of Oddi. Morphine contraction is antagonized by naloxone, competitively on the sphincter, noncompetitively on the bile duct. Diphenhydramine at low concentration (3.4 X 10(-6)M) also antagonizes both actions of morphine. Histamine has a very potent contracting action on the sphincter and bile duct and this is antagonized by diphenhydramine. Burimamide only weakly antagonizes the actions of morphine or histamine. Compound 48/80 causes a pronounced contraction of sphincter and bile duct following which morphine effects are greatly attenuated. These results suggest that morphine-induced contraction of the sphincter of Oddi and bile duct is mediated by a two step reaction involving interaction with a specific opiate receptor leading to the release of histamine which combines with an H1 receptor to produce the effect. |
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