Uptake of acetylated LDL by peritoneal macrophages obtained from normal and Watanabe heritable hyperlipidemic rabbits, an animal model for familial hypercholesterolemia |
| |
Authors: | K Ishii T Kita N Kume Y Nagano C Kawai |
| |
Institution: | Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan. |
| |
Abstract: | Acetylated low-density lipoprotein (acetyl-LDL) stimulated the incorporation of 14C]oleate into cholesteryl 14C]oleate in peritoneal macrophages from both normal and Watanabe heritable hyperlipidemic (WHHL) rabbits. A degradation study showed that macrophages from WHHL rabbits degraded the same amount of 125I-labeled acetyl-LDL as macrophages from normal rabbits. These findings indicate that macrophages of WHHL rabbits have functional acetyl-LDL receptors. |
| |
Keywords: | |
|
|