Clonal turnover of enterohemorrhagic Escherichia coli O157:H7 in experimentally infected cattle |
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| Authors: | Akiba M Sameshima T Nakazawa M |
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| Affiliation: | Laboratory of Zoonosis, Feed Safety Research Division, National Institute of Animal Health, Kannondai 3-1-1, Tsukuba, Ibaraki, Japan. akiba@sat.affrc.go.jp |
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| Abstract: | A total of 401 enterohemorrhagic Escherichia coli (EHEC) O157:H7 isolates from two experimentally infected calves were analyzed using molecular biological methods. Genetic differences detected by pulsed-field gel electrophoresis were observed between the inoculated and recovered strains as early as 1 day post inoculation. The loss of the inoculated clone was observed in one calf. Replication and dissemination of the EHEC O157:H7 strains that mutated in cattle may result in the diversification of this organism among cattle populations. |
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| Keywords: | Escherichia coli O157:H7 Clonal turnover Cattle |
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