Continuous production of L-malic acid by immobilized cells |
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| Authors: | Ichiro Chibata Tetsuya Tosa Isao Takata |
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| Affiliation: | Department of Biochemistry, Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd, 16-89, Kashima-3-chome, Yodogawa-ku, Osaka, Japan |
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| Abstract: | l-Malic acid is used extensively in the pharmaceutical industry and as a food additive. It is now produced on an industrial scale by the enzymatic conversion of fumaric acid using immobilized cells of Brevibacterium flavum. Recent improvements to this system, especially the use of x-carrageenan supports, have resulted in a continuous process capable of yielding 30 tonnes of l-malic acid per month. |
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