Lipid activators of protein kinase C |
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Authors: | V P Chauhan A Chauhan D S Deshmukh H Brockerhoff |
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Institution: | New York State Institute for Basic Research in Developmental Disabilities, Staten Island 10314. |
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Abstract: | Among the many reported lipid activators of protein kinase C only those of high affinity can be considered true physiological effectors, at present the tumor promoters, e.g., phorbol esters; 1,2-diacyl-sn-glycerols; and phosphatidylinositol 4,5-bisphosphate. Many other compounds (including arachidonic acid) are activators at high, unphysiological concentrations only, and they seem to be sterically unsuited for bonding to the enzyme. Such pseudo-activators possibly act by scrambling the structure of the regulatory moiety of the kinase. |
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