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No evidence for DUP25 in patients with panic disorder using a quantitative real-time PCR approach |
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| Authors: | Johannes Schumacher Andreas C. J. Otte Tim Becker Yuli Sun Thomas F. Wienker Brunhilde Wirth Petra Franke Rami Abou Jamra Peter Propping Jürgen Deckert Markus M. Nöthen Sven Cichon |
| Affiliation: | (1) Institute of Human Genetics, University of Bonn, Wilhelmstrasse 31, 53111 Bonn, Germany;(2) Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany;(3) Department of Psychiatry, University of Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany;(4) Department of Psychiatry, University of Münster, Albert-Schweitzer-Strasse 11, 48129 Münster, Germany;(5) Department of Medical Genetics, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium;(6) Institute of Humangenetics, University of Köln, Kerpenerstr. 34, 50931 Köln, Germany |
| Abstract: | A duplication of chromosome 15q24-q26 (DUP25) has been reported to be associated with anxiety disorders. We tested for the presence of DUP25 in a sample of 50 patients with panic disorder and 50 controls using a quantitative real-time PCR approach. Contrary to the original finding, our results were compatible with the absence of DUP25, and no significant difference could be detected between patients and controls (P=1.0). Thus, our study does not support the hypothesis of an involvement of DUP25 in panic disorder. |
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