The microRNA-127-3p directly targeting Vamp2 in C2C12 myoblasts |
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Authors: | Jie Li Gaofu Wang Jing Jiang Lin Fu Peng Zhou |
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Affiliation: | Herbivorous Livestock Institute, Chongqing Academy of Animal Sciences, Chongqing, People's Republic of China |
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Abstract: | MicroRNAs (miRNAs) have been reported that can regulate skeletal muscle growth and development. Previously, we demonstrated that miR-127-3p were differently expressed in skeletal muscle and muscle cells. However, the molecular mechanism of miR-127-3p regulation of skeletal myogenesis are not well elucidated. In this study, we transfected miR-127-3p into C2C12 cells, and found miR-127-3p induces myogenesis by targeting Vamp2. Moreover, the regulatory mechanism of Vamp2 in myoblasts proliferation and differentiation was further confirmed. In conclusion, our data providedevidences that miR-127-3p reciprocally regulated myoblasts proliferation and differentiation through directly targeting Vamp2. |
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Keywords: | Myogenesis miR-127-3p Vamp2 C2C12 |
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