Inhibition of cell growth by cellular differentiation into adipocyte-like cells in dexamethasone sensitive cancer cell lines |
| |
| Authors: | Hea-In Kim Sun-Ha Moon Won-Cheol Lee Hyeon-Jeong Lee Sharath Belame Shivakumar Sung-Ho Lee |
| |
| Institution: | 1. Department of Biology Education, Gyeongsang National University, Jinju, Republic of Korea;2. OBS/Theriogenology and Biotechnology, Gyeongsang National University, Jinju, Republic of Korea;3. Division of Life Science, Gyeongsang National University, Jinju, Republic of Korea |
| |
| Abstract: | The stress responses in human body lead to secretion of cortisol hormone. The present study investigated the cellular responses on cell growth and cellular differentiation into adipocytes by exposure of synthetic stress hormone, dexamethasone (DEX) in various human cancer and normal cells. After prolonged exposure of cells with 1?μg/ml DEX for 2 weeks, population doubling time (PDT) was significantly (P?P?P?β (GRβ) and peroxisome proliferator-activated receptor γ (PPARγ) were significantly (P?P?
|
| |
| Keywords: | Human cancer dexamethasone cell differentiation adipocytes |
|
|
