CD4 and CD8 may adopt a similar mode of binding to their MHC ligands. |
| |
| Authors: | R I Brinkworth |
| |
| Affiliation: | Centre for Drug Design and Development, University of Queensland, Brisbane, Australia. |
| |
| Abstract: | A theoretical scheme is proposed by which the type-specific cell surface receptors of T-lymphocytes, CD8 and CD4, bind class I and II MHC proteins in a similar manner. The scheme has equivalent residues in the C'/C' loop-C' strand-C'/D loop region in domain 1 of CD4 and CD8 alpha binding to equivalent residues in the C and D beta-strands and C/D loops in HLA-DR beta 2 (class II) and HLA-A2 alpha 3 (class I) respectively through a series of electrostatic, hydrogen and hydrophobic bonds. |
| |
| Keywords: | |
|
|
