IL-2 is not required for the initiation of CD8 T cell cycling but sustains expansion |
| |
Authors: | D'Souza Warren N Lefrançois Leo |
| |
Institution: | Department of Medicine, Division of Immunology, University of Connecticut Health Center, Farmington, CT 06030, USA. |
| |
Abstract: | Based primarily on in vitro data, IL-2 is believed to be the key cytokine for initiation of the cell cycle of activated T cells. However, the role of IL-2 remains unresolved for T cell responses in vivo. We examined whether the absence of IL-2-mediated signaling in CD8 T cells affected initiation of proliferation. Our results conclusively demonstrated that initial division of Ag-specific CD8 T cells following priming was IL-2 independent, regardless of the context in which Ag was presented. In contrast, the latter stage of the proliferative phase was IL-2-dependent, particularly in nonlymphoid tissues. Thus, activated CD8 T cells initially undergo IL-2-independent proliferation, but reach a critical juncture where the requirement for IL-2 as a growth factor gains prominence. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|