Minimal Rev-response element for type 1 human immunodeficiency virus. |
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| Authors: | X J Huang T J Hope B L Bond D McDonald K Grahl and T G Parslow |
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| Institution: | Department of Pathology, University of California, San Francisco 94143-0506. |
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| Abstract: | Rev protein regulates nuclear export of viral mRNAs that contain a 240-base RNA sequence termed the Rev-response element (RRE). We demonstrate that an 88-base truncated RRE encompassing a known Rev binding site can mediate Rev responsiveness in vivo. Two tandem copies of this mutant function as efficiently as the full-length RRE. |
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