Effect of Pro11Ala substitution on the structural and functional properties of antimicrobial peptide buforin 2 |
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| Authors: | T. V. Naumenkova M. Yu. Antonov I. N. Nikolaev K. V. Shaitan |
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| Affiliation: | 1. Moscow State University, Moscow, 119991, Russia
2. North-Eastern Federal University, Yakutsk, 677000, Russia
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| Abstract: | Molecular dynamics simulations were used to investigate the spatial structure of antimicrobial peptide buforin 2 in water and in toroidal transmembrane pores. It is shown that replacement of Pro11 with Ala straightens and stabilizes the helix and enables the peptide to form a stable transmembrane toroidal pore. The results obtained correlate with the changes observed when the modified buforin 2 interacts with cells. |
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