Interleukin 2: from immunostimulation to immunoregulation and back again |
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Authors: | Bachmann Martin F Oxenius Annette |
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Affiliation: | Cytos Biotechnology AG, Wagistrasse 25, 8952 Zürich-Schlieren, Switzerland. martin.bachmann@cytos.com |
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Abstract: | Interleukin 2 (IL-2) was one of the first cytokines to be discovered. However, the complex role of IL-2 and its receptor in the regulation of immune responses is only now emerging. This review explores the various signals triggered by IL-2 and discusses their translation into biological function. A model is outlined that accommodates the seemingly contradictory functions of IL-2, and explains how one cytokine can be an essential T-cell growth and differentiation factor and yet also be indispensable to maintain peripheral tolerance. |
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Keywords: | adaptive immunity immune regulation immune stimulation interleukin 2 T lymphocyte |
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