The Effects of Atractyloside and Bongkrekic Acid on Jerusalem Artichoke Mitochondria in Relation to Adenine Nucleotide Translocation

The translocation of ADP and ATP across the inner membrane ofJerusalem artichoke mitochondria is demonstrated. Atractyloside,a competitive inhibitor of the adenine nucleotide translocatorof mammalian mitochondria, is without effect in artichoke mitochondriawhen added at concentrations normally inhibitory in the animalsystem. Bongkrekic acid, a noncompetitive inhibitor, inhibitsthe adenine nucleotide-dependent processes of artichoke andmammalian mitochondria at similar concentrations. The effectsof atractyloside and bongkrekic acid in relation to adeninenucleotide translocation are discussed.