Design and synthesis of 3-(4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridin-2-yl)-1H-quinolin-2-ones as VEGFR-2 kinase inhibitors |
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| Authors: | Han Sun-Young Choi Jie Won Yang Jeon Chae Chong Hack Lee Jongkook Jung Heejung Lee Kwangho Ha Jae Du Kim Hyoung Rae Cho Sung Yun |
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| Institution: | Bio-Organic Science Division, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea. |
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| Abstract: | A series of 3-(4,5,6,7-tetrahydro-3H-imidazo4,5-c]pyridin-2-yl)-1H-quinolin-2-ones have been identified as a new class of VEGFR-2 kinase inhibitors. A variety of (4,5,6,7-tetrahydro-imidazo5,4-c]pyridin-2-yl)-acetic acid ethyl esters were synthesized, and their VEGFR-2 inhibitory activity was evaluated. Described herein are the preparation of the series and the effects of the compounds on VEGFR-2 kinase activity. |
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