Molecular Determinants that Regulate Plasma Membrane Association of HIV-1 Gag |
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| Authors: | Vineela Chukkapalli |
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| Institution: | Department of Microbiology and Immunology, University of Michigan Medical School, 5736 Medical Science Building II, 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA |
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| Abstract: | Human immunodeficiency virus type 1 assembly is a multistep process that occurs at the plasma membrane (PM). Targeting and binding of Gag to the PM are the first steps in this assembly process and are mediated by the matrix domain of Gag. This review highlights our current knowledge on viral and cellular determinants that affect specific interactions between Gag and the PM. We will discuss potential mechanisms by which the matrix domain might integrate three regulatory components, myristate, phosphatidylinositol-(4,5)-bisphosphate, and RNA, to ensure that human immunodeficiency virus type 1 assembly occurs at the PM. |
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| Keywords: | HIV-1 human immunodeficiency virus type 1 MA matrix HBR highly basic region PI(4 5)P2 phosphatidylinositol-(4 5)-bisphosphate CA capsid NC nucleocapsid PM plasma membrane WT wild type IP6 inositol hexakisphosphate PS phosphatidylserine PIP phosphatidylinositol phosphate |
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