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Elevated copper remodels hepatic RNA processing machinery in the mouse model of Wilson's disease
Authors:Burkhead Jason L  Ralle Martina  Wilmarth Phillip  David Larry  Lutsenko Svetlana
Institution:
  • 1 University of Alaska Anchorage, Anchorage, AK 99508, USA
  • 2 Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, OR 97239, USA
  • 3 Department of Physiology, Johns Hopkins University, Baltimore, MD 21230, USA
  • Abstract:
    Keywords:WD  Wilson's disease  MT  metallothionein  SRXF  synchrotron radiation X-ray fluorescence  ICP-MS  inductively coupled plasma mass spectrometry  CPM  7-diethylamino-3-(4&prime  -maleimidylphenyl)-4-methylcoumarin  2D-DIGE  two-dimensional differential gel electrophoresis  16-BAC  16-benzyldimethyl-n-hexadecyl ammonium chloride  ROI  regions of interest  CAPS  N-cyclohexyl-3-aminopropanesulfonic acid  PBS  phosphate-buffered saline  HRP  horseradish peroxidase  GAPDH  glyceraldehyde 3-phosphate dehydrogenase
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