| 新型生物材料聚(乳酸-苯丙氨酸)的直接熔融聚合法制备与表征 |
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| 引用本文： | 侯晓娜,汪朝阳,罗玉芬,叶瑞荣.新型生物材料聚(乳酸-苯丙氨酸)的直接熔融聚合法制备与表征[J].氨基酸和生物资源,2008,30(2):27-30. |
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| 作者姓名： | 侯晓娜 汪朝阳 罗玉芬 叶瑞荣 |
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| 作者单位： | 华南师范大学化学与环境学院化学系,广东广州,510006;华南师范大学化学与环境学院化学系,广东广州,510006;华南师范大学化学与环境学院化学系,广东广州,510006;华南师范大学化学与环境学院化学系,广东广州,510006 |
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| 摘 要： | 直接以廉价的外消旋乳酸(D,L-LA)和苯丙氨酸(Phe)为原料,以氧化亚锡为催化剂,采用熔融聚合法合成了新型生物材料聚(乳酸-苯丙氨酸)共聚物。用特性粘数η]、FTIR、1HNMR、DSC、GPC、XRD等进行系统表征,并考察了不同投料比对共聚物的影响。随着投料比中苯丙氨酸含量n(Phe)的增加,共聚物由一定的结晶性逐渐转变为无定形态。所得共聚物的Mw在2700~3900之间,能满足该生物降解材料在药物缓释领域中的应用。
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| 关 键 词： | 苯丙氨酸 聚(乳酸-苯丙氨酸)共聚物 生物材料 直接熔融聚合 合成 |
Direct Synthesis of Novel Biomaterial Poly (lactic acid-co-Phenyl-alanine)via Melt Copolycondensation and Its Characterization |
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| HOU Xiao-na,WANG Zhao-yang,LUO Yu-fen,YE Rui-rong.Direct Synthesis of Novel Biomaterial Poly (lactic acid-co-Phenyl-alanine)via Melt Copolycondensation and Its Characterization[J].Amino Acids & Biotic Resources,2008,30(2):27-30. |
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| Authors: | HOU Xiao-na WANG Zhao-yang LUO Yu-fen YE Rui-rong |
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| Abstract: | Using cheap D,L-lactic acid(D,L-LA) and phenylalanine(Phe) as material,and SnO as catalyst,novel biomaterial poly(lactic acid-co-phenylalanine) P(LA-co-Phe)] was directly synthesized via melt copolycondensation. The copolymer was systematically characterized with intrinsic viscosity η],FTIR,1H NMR,DSC,XRD and GPC.The effects of different feed molar ratio were discussed.With the increase of the feed molar ratio of Phe,the crystallinity of copolymer gradually disappeared.Their weight-average molecular weight(Mw) was between 2700 and 3900,which could meet the request for the application in drug delivery of this biodegradable material. |
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| Keywords: | phenylalanine poly(lactic acid-co-phenylalanine) biomaterial direct melt copolycondensation synthesis |
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