Close correlation of streptococcal DNase B (sdaB) alleles with emm genotypes in Streptococcus pyogenes |
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| Authors: | Matsumoto Masakado,Sakae Kenji,Hashikawa Shinnosuke,Torii Keizo,Hasegawa Tadao,Horii Toshinobu,Endo Miyoko,Okuno Rumi,Murayama Shoko,Hirasawa Kyoko,Suzuki Rieko,Isobe Junko,Tanaka Daisuke,Katsukawa Chihiro,Tamaru Aki,Tomita Masaaki,Ogata Kikuyo,Ikebe Tadayoshi,Watanabe Haruo,Ohta Michio Working Group for Group A Streptococci in Japan |
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| Affiliation: | Department of Microbiology, Aichi Prefectural Institute of Public Health, Nagoya, Japan. masakado_matsumoto@pref.aichi.lg.jp |
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| Abstract: | DNase B is a major nuclease and a possible virulence factor in Streptococcus pyogenes. The allelic diversity of streptococcal DNase B (sdaB) gene was investigated in 83 strains with 14 emm genotypes. Of the 15 alleles identified, 11 alleles carried only synonymous nucleotide substitutions. On the other hand, 4 alleles had a non-synonymous substitution other than synonymous substitutions, resulting in the substitution of a single amino acid. The distribution of each allele was generally emm genotype-specific. Only sdaB7 was found in both emm2 and emm4. The promoter region was highly conserved and DNase B protein was similarly expressed in all alleles. |
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| Keywords: | sdaB gene emm genotype streptococcus pyogenes |
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