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Close correlation of streptococcal DNase B (sdaB) alleles with emm genotypes in Streptococcus pyogenes |
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| Authors: | Matsumoto Masakado Sakae Kenji Hashikawa Shinnosuke Torii Keizo Hasegawa Tadao Horii Toshinobu Endo Miyoko Okuno Rumi Murayama Shoko Hirasawa Kyoko Suzuki Rieko Isobe Junko Tanaka Daisuke Katsukawa Chihiro Tamaru Aki Tomita Masaaki Ogata Kikuyo Ikebe Tadayoshi Watanabe Haruo Ohta Michio;Working Group for Group A Streptococci in Japan |
| Institution: | Department of Microbiology, Aichi Prefectural Institute of Public Health, Nagoya, Japan. masakado_matsumoto@pref.aichi.lg.jp |
| Abstract: | DNase B is a major nuclease and a possible virulence factor in Streptococcus pyogenes. The allelic diversity of streptococcal DNase B (sdaB) gene was investigated in 83 strains with 14 emm genotypes. Of the 15 alleles identified, 11 alleles carried only synonymous nucleotide substitutions. On the other hand, 4 alleles had a non-synonymous substitution other than synonymous substitutions, resulting in the substitution of a single amino acid. The distribution of each allele was generally emm genotype-specific. Only sdaB7 was found in both emm2 and emm4. The promoter region was highly conserved and DNase B protein was similarly expressed in all alleles. |
| Keywords: | sdaB gene emm genotype streptococcus pyogenes |
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