Actin-based motility: stop and go with Ena/VASP proteins |
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| Authors: | Reinhard M Jarchau T Walter U |
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| Affiliation: | 1. Institute of Physics, Natl. Acad. of Sci. of Ukraine. Prospect Nauky, 46, Kyiv 03028, Ukraine;2. Taras Shevchenko National University of Kyiv, Prospect Glushkova, 4g, Kyiv 03127, Ukraine;1. Unità di Medicina III, ASST Santi Paolo e Carlo, Dipartimento di Scienze della Salute, Università degli Studi di Milano, Milano, Italy;2. Centro Diagnostico Italiano, Milano, Italy;3. Dipartimento Cardiovascolare, Policlinico S. Orsola, Bologna, Italy;4. Semeion Research Centre, Roma, Italy;5. Unità Coronarica IRCCS Policlinico San Matteo, Pavia, Italy;6. Divisione di Cardiologia, Seconda Università di Napoli, Napoli, Italy;7. Dipartimento di Medicina e Chirurgia, Schola Medica Salernitana, Università di Salerno, Salerno, Italy;8. Unità di Cardiologia, Servizio di Emodinamica, Istituto Ospedaliero Fondazione Poliambulanza, Brescia, Italy;9. Divisione di Cardiologia, Ospedale Santo Stefano, Prato, Italy;10. Ospedale del Cuore, Fondazione Toscana Gabriele Monasterio, Massa, Italy;11. Dipartimento Cardiotoracico e Vascolare, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy;12. Ospedale Ferrarotto, Università di Catania, Catania, Italy;13. The Cardiovascular Research Foundation, New York, NY, USA |
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| Abstract: | Proteins of the Ena/VASP (Enabled/vasodilator-stimulated phosphoprotein) family are involved in Abl and/or cyclic nucleotide-dependent protein kinase signaling pathways. These proteins are also crucial factors in regulating actin dynamics and associated processes such as cell-cell adhesion, platelet function and actin-based motility of both cytopathogenic Listeria and their eukaryotic host cells. Although biochemical mechanisms have emerged depicting Ena/VASP proteins as enhancers of actin filament formation, increasing evidence also suggests that these proteins have inhibitory functions in integrin regulation, cell motility and axon guidance. |
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