Hypoxia-Ischemia Disrupts Directed Interactions within Neonatal Prefrontal-Hippocampal Networks |
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Authors: | Marco D Brockmann Maja Kukovic Michael Sch?nfeld Jan Sedlacik Ileana L Hanganu-Opatz |
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Institution: | 1. Developmental Neurophysiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; 2. Department of Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Charité University Medicine Berlin, Germany, |
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Abstract: | Due to improved survival rates and outcome of human infants experiencing a hypoxic-ischemic episode, cognitive dysfunctions have become prominent. They might result from abnormal communication within prefrontal-hippocampal networks, as synchrony and directed interactions between the prefrontal cortex and hippocampus account for mnemonic and executive performance. Here, we elucidate the structural and functional impact of hypoxic-ischemic events on developing prefrontal-hippocampal networks in an immature rat model of injury. The magnitude of infarction, cell loss and astrogliosis revealed that an early hypoxic-ischemic episode had either a severe or a mild/moderate outcome. Without affecting the gross morphology, hypoxia-ischemia with mild/moderate outcome diminished prefrontal neuronal firing and gamma network entrainment. This dysfunction resulted from decreased coupling synchrony within prefrontal-hippocampal networks and disruption of hippocampal theta drive. Thus, early hypoxia-ischemia may alter the functional maturation of neuronal networks involved in cognitive processing by disturbing the communication between the neonatal prefrontal cortex and hippocampus. |
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