Meta-Analysis: Prognostic Value of Survivin in Patients with Hepatocellular Carcinoma |
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Authors: | Jin Long Liu Xue Jun Zhang Zhao Zhang An Hong Zhang Wei Wang Jia Hong Dong |
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Affiliation: | 1. Department of Hepatobiliary Surgery, The Chinese PLA General Hospital, Beijing, China.; 2. Department of General Surgery 1, The Affiliated Hospital of Chengde Medical College, Chengde City, China.; 3. Department of Vascular Surgery, The People’s Liberation Army 252 Hospital, Baoding City, China.; Xiangya Hospital of Central South University, China, |
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Abstract: | BackgroundThe expression of survivin is a promising prognostic indicator for some carcinomas. However, evidence for the prognostic value of survivin with respect to survival in hepatocellular carcinoma remains controversial.AimTo conduct a systematic review of studies evaluating survivin expression in hepatocellular carcinoma as a prognostic indicator.MethodsThe relevant literature was searched using PubMed, EMBASE, and Chinese biomedicine databases, and two meta-analyses were performed. One studied the association between survivin expression and the overall survival of patients with hepatocellular carcinoma, whereas the other studied the association between survivin expression and disease-free survival. Studies were pooled, and summary hazard ratios (HRs) were calculated. Subgroup analyses were also conducted.ResultsFourteen eligible studies with a total of 890 patients were included in this study. Two meta-analyses were performed according to the different outcomes by which prognosis was valued. The combined HR of the overall survival studies was 2.33 (95% CI: 1.65–3.31). The combined HR of disease-free survival studies was 2.13 (95% CI: 1.65–2.75). These data appeared to be significant when stratified by detection method, the language of publication, and HR estimate. The heterogeneities were highly significant (I2>50%) when subgroup analyses of overall survival rate were conducted, whereas little heterogeneity was found when subgroup analyses of disease-free survival rate were carried out. The positive expression of survivin in the cytoplasm was significantly correlated with poor prognosis in HCC (HR>1).ConclusionsThis study showed that survivin expression was correlated with poor prognosis in patients with hepatocellular carcinoma, regardless whether they were assessed by overall survival or disease-free survival. |
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