AMPK: An odyssey of a metabolic regulator,a tumor suppressor,and now a contextual oncogene |
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Institution: | Molecular and Cellular Oncology Laboratory, Department of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad 500046, Telangana, India |
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Abstract: | Metabolic reprogramming is a unique but complex biochemical adaptation that allows solid tumors to tolerate various stresses that challenge cancer cells for survival. Under conditions of metabolic stress, mammalian cells employ adenosine monophosphate (AMP)-activated protein kinase (AMPK) to regulate energy homeostasis by controlling cellular metabolism. AMPK has been described as a cellular energy sensor that communicates with various metabolic pathways and networks to maintain energy balance. Earlier studies characterized AMPK as a tumor suppressor in the context of cancer. Later, a paradigm shift occurred in support of the oncogenic nature of AMPK, considering it a contextual oncogene. In support of this, various cellular and mouse models of tumorigenesis and clinicopathological studies demonstrated increased AMPK activity in various cancers. This review will describe AMPK's pro-tumorigenic activity in various malignancies and explain the rationale and context for using AMPK inhibitors in combination with anti-metabolite drugs to treat AMPK-driven cancers. |
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Keywords: | AMPK"} {"#name":"keyword" "$":{"id":"pc_IeMnooVi2M"} "$$":[{"#name":"text" "_":"Adenosine monophosphate (AMP)-activated protein kinase HIF1α"} {"#name":"keyword" "$":{"id":"pc_bRm5MYcH4X"} "$$":[{"#name":"text" "_":"Hypoxia-inducible factor 1-alpha CBS domains"} {"#name":"keyword" "$":{"id":"pc_Nr1PMHw2Nb"} "$$":[{"#name":"text" "_":"Cystathionine-β-synthase domains LKB1"} {"#name":"keyword" "$":{"id":"pc_v10lDHUbLI"} "$$":[{"#name":"text" "_":"Liver kinase B1 |
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