Transport of Intact Porphyrin by HpuAB, the Hemoglobin-Haptoglobin Utilization System of Neisseria meningitidis |
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| Authors: | L. A. Lewis M.-H. Sung M. Gipson K. Hartman D. W. Dyer |
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| Affiliation: | Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73103 |
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| Abstract: | The meningococcal hemA gene was cloned and used to construct a porphyrin biosynthesis mutant. An analysis of the hemA mutant indicated that meningococci can transport intact porphyrin from heme (Hm), hemoglobin (Hb), and Hb-haptoglobin (Hp). By constructing a HemA− HpuAB− double mutant, we demonstrated that HpuAB is required for the transport of porphyrin from Hb and Hb-Hp. |
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