Genes for 7S RNAs can replace the gene for 4.5S RNA in growth of Escherichia coli. |
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| Authors: | S Brown |
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| Institution: | Laboratory of Chromosome Biology, National Cancer Institute-Frederick Cancer Research and Development Center, Maryland 21702. |
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| Abstract: | 4.5S RNAs of eubacteria and 7S RNAs of archaebacteria and eukaryotes exist in a hairpin conformation. The apex of this hairpin displays structural and sequence similarities among both 4.5S and 7S RNAs. Furthermore, a hyphenated sequence of 16 nucleotides is conserved in all eubacterial 4.5S RNAs examined. In this article I report that 7S RNAs that contain this 16-nucleotide sequence are able to replace 4.5S RNAs and permit growth of Escherichia coli. |
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