Refined genetic mapping of X-linked Charcot-Marie-Tooth neuropathy. |
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| Authors: | P R Fain D F Barker and P F Chance |
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| Institution: | Department of Medical Informatics, University of Utah School of Medicine, Salt Lake City 84108. |
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| Abstract: | Genetic linkage studies were conducted in four multigenerational families with X-linked Charcot-Marie-Tooth disease (CMTX), using 12 highly polymorphic short-tandem-repeat markers for the pericentromeric region of the X chromosome. Pairwise linkage analysis with individual markers confirmed tight linkage of CMTX to the pericentromeric region in each family. Multipoint analyses strongly support the order DXS337-CMTX-DXS441-(DXS56,PGK1). |
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