Novel amino-Li resin for water-based solid-phase peptide synthesis |
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| Authors: | Christina Uth Simon Englert Olga Avrutina Harald Kolmar Sascha Knauer |
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| Affiliation: | 1. Sulfotools GmbH, Rüsselsheim am Main, Germany;2. Clemens-Schöpf Institute for Organic Chemistry and Biochemistry, Technical University of Darmstadt, Darmstadt, Germany |
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| Abstract: | We report the first application of a novel amino-Li resin to water-based solid-phase peptide synthesis (SPPS) applying the Smoc-protecting group approach. We demonstrated that it is a suitable support for the sustainable water-based alternative to a classical SPPS approach. The resin possesses good swelling properties in aqueous milieu, provides significant coupling sites, and may be applicable to the synthesis of difficult sequences and aggregation-prone peptides. |
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| Keywords: | ASPPS Smoc strategy solid support sustainable peptide synthesis water-based peptide synthesis |
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