Isolation of a cigarette smoke fraction responsible for the inhibition of benzo[a]pyrene metabolism in the isolated perfused rabbit lung |
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Authors: | M Bialer S D Sloneker H B Kostenbauder |
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Institution: | University of Kentucky, College of Pharmacy, Lexington, KY 40506 U.S.A. |
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Abstract: | Among the several thousand components of cigarette smoke is a substance or substances capable of inhibiting pulmonary metabolism of nicotine and altering the metabolite profile of procarcinogens such as benzoa]pyrene (BP). This substance(s) inhibits BP metabolism in the lung in amounts present in a few puffs of cigarette smoke. By a series of extractions and chromatographic methods an active subfraction containing only 1% of the total cigarette smoke condensate (CSC), was isolated. This fraction demonstrated the same inhibition of BP metabolism in the isolate perfused lung (IPL) as the whole smoke. The inhibitor(s) present in this fraction possess amphoteric characteristics. The acidic function is believed to be a phenolic one. |
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Keywords: | Cigarette smoke Isolated perfused rabbit lung BP CSC cigarette smoke condensate IPL isolated perfused rabbit lung PAH polyaromatic hydrocarbons TLC thin-layer chromatography |
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